Questar, an international Bioinformatics company, to jointly exploit a selected number of putative proteins from the AlphaGene novel inventory. Questar will provide extensive bioinformatic support for structure determination, pathway identification, and the creation of a library of potential small molecule ligands for in-silico screening of the small molecules. In addition, Questar will provide standardization of database construction and will develop new algorithms for data mining.

 



Lahey Clinic, a group practice of 500 physicians and 4,000 support staff, to study the molecular genetics of prostate cancer. This agreement will initially investigate the role of prostate-specific carcinoembryonic antigen (CEA), recently discovered by AlphaGene's scientists, as a diagnostic and prognostic marker. Simultaneously, this collaboration will examine additional genomic and proteomic methods to understand the molecular biology of prostate cancer, and possible treatment monitoring protocols.

Wayne State University, a leading academic institution located in Detroit , Michigan, to develop a better understanding of epilepsy. The agreement will combine the epilepsy expertise of Wayne State University with the gene expression capabilities of AlphaGene. The collaboration seeks to identify the genes involved in the disease pathways, locate logical points of drug intervention, and develop new therapeutic options in order to provide a better quality of life for patients with epilepsy.

DoubleTwist, Inc., a leading e-commerce portal to the genetic code,  to make the AlphaGene gene inventory available to every life scientist. The collaboration provides researchers with access to AlphaGene's proprietary cDNA sequence data through DoubleTwist.com. A DoubleTwist user researching a partial-length DNA sequence will automatically receive notification when a corresponding full-length cDNA exists in AlphaGene's database. AlphaGene will give the DoubleTwist user an opportunity to license or purchase the clone.

PerkinElmer, previously NEN Life Science Products ("NEN"), whereby AlphaGene designs, develops, and manufactures a line of gene expression biochips, which PerkinElmer markets and distributes. The MicroMAX line of microarrays (MICROMAX™ Human cDNA Microarray System I ) contains known genes from the AlphaGene gene inventory. 

This agreement has resulted in the development of seven microarrays, one 2,400 gene chip and 6 focused arrays: Kinase and Phosphatase, Transcription Factors, Human Cancer, Ion Channels, Apoptosis, and Neuroscience.

Genetics Institute, now part of Wyeth, a division of American Home Products, to provide Genetics Institute ("GI") with access to AlphaGene's full-length, novel human genes encoding for secreted proteins as part of the DiscoverEase library. AlphaGene was the largest outside supplier of GI DiscoverEase clones.

In addition, AlphaGene has provided various genomic services from library construction to sequencing for over a dozen customers. 

For example, AlphaGene has provided services to the following outstanding biotechnology companies:

	Eos Biotechnology, Inc.
	Exelexis, Inc.
	Tularik Inc.